President Obama will appoint Denis McDonough as his new chief of staff on Friday, a White House official tells POLITICO.

Obama will make the long-expected announcement at 12:10 p.m. in the East Room.

The White House will also announce several other promotions Friday, including moving communications director Dan Pfeiffer to the job of senior adviser, and shifting deputy communications director Jennifer Palmieri into Pfeiffer's old job. Pfeiffer's move comes as David Plouffe, a longtime Obama political adviser, plans to leave the White House this month.

Other senior-level moves include: 

Rob Nabors – Assistant to the President and Deputy White House Chief of Staff for Policy
Tony Blinken – Assistant to the President and Deputy National Security Advisor
Danielle Gray – Assistant to the President and Cabinet Secretary              
Katy Kale – Assistant to the President for Management and Administration
Lisa Monaco – Assistant to the President and Deputy National Security Advisor for Homeland Security and Counterterrorism (upon confirmation of John Brennan as DCIA)
Miguel Rodriguez –Assistant to the President and Director of Legislative Affairs
David Simas – Assistant to the President and Deputy Senior Advisor for Communications and Strategy