EMAIL DETAILS

Ok with me too. Just send me a number to call in to

Thanks
Cassian
206 218 7181

Sent from my iPhone

> On Mar 10, 2015, at 9:20 AM, Patrick Soon-Shiong <pss@nantworks.com> wrote:
>
> Hi Howard
> This works for me.
> Marci and Phil please pull me out of my meeting to do the call
>
> Sent from my BlackBerry 10 smartphone on the Verizon Wireless 4G LTE network.
> From: Howard Krein
> Sent: Monday, March 9, 2015 6:33 PM
> To: Yung,W K Alfred
> Cc: Patrick Soon-Shiong; Mark Hyman; Hunter Biden; Hallie Biden; Beau Biden; Kim Nicholson; Phil Yang; Marci Rodriguez; Shahrooz Rabizadeh; Mills,Gordon B; Hwu,Patrick; Chin,Lynda; Cassian Yee; Shaw,Kenna R; DePinho,Ronald A
> Subject: Re: next steps
>
> Al and Patrick,
> As long as tomorrow at 4pm PST (7am Hong Kong) works I will send call in number for the three of us to connect and further discuss options/plans as well serve as an introduction.
> thanks again and looking forward to speaking with both of you tomorrow evening.
> Warmly,
> Howard
>
>> On Mon, Mar 9, 2015 at 8:16 PM, Yung,W K Alfred <wyung@mdanderson.org> wrote:
>> We have done deep molecular analysis on Beau's original tumor with our T200 panel and WGS. The profile is quite bland, not too many mutations is found, major GBM associated genes like EGFR, PTEN, PIK3CA, PDGFRA, HER2 are negative, only 2 positive hits: p53 and PTPN11. IHC showed increase pAKT, PDGFRA, pMAPK. Patrick's team have identified 10 over-expressed peptides for the preparation of an immuned-T-cell vaccine which we planned to use with the anti-PD1.
>> I certainly welcome any help we can get. We have planned to do another round of deep molecule analysis of the new tumor after it is removed next week.
>> Al
>>
>>
>> W. K. Alfred Yung, M.D.
>> Chair,Department of Neuro-Oncology
>> UT M.D. Anderson Cancer Center
>> 1515 Holcombe Blvd.
>> Houston, TX 77030
>> 713-794-1285
>>
>>
>> From: Patrick Soon-Shiong <pss@nantworks.com>
>> Date: Monday, March 9, 2015 9:36 AM
>> To: Howard Krein <howard@startuphealth.com>, Mark Hyman <Mark@ultrawellnesscenter.com>
>> Cc: Hunter Biden <rhb@rspdc.com>, Hallie Beiden <halliebiden@gmail.com>, Beau Biden <261penn@gmail.com>, Alfred Yung <wyung@mdanderson.org>, Kim Nicholson <Kim.Nicholson@swedish.org>, Phil Yang <phil.yang@nantworks.com>, Marci Rodriguez <Marci.Rodriguez@nantworks.com>, Shahrooz Rabizadeh <Shahrooz@nantworks.com>
>> Subject: Re: next steps
>>
>>
>> Dear Howard and Mark
>> Happy to help in anyway we can. As a first step we should retieve the tissue (both the paraffin block and the fresh frozen) from the surgery performed a year ago. We could begin the panomic sequencing on that sample now and before the next surgery. We will look for eGfr and Her+ markers as potential targets for the NK92 treatment.
>>
>> Kim will reach out to you today. Also will coordinate a call for Tuesday with our team to review all images to date
>>
>> Keep well
>> Patrick
>> Sent from my BlackB
>> erry 10 smartphone on the Verizon Wireless 4G LTE network.
>> From: Howard Krein
>> Sent: Monday, March 9, 2015 5:36 AM
>> To: Mark Hyman
>> Cc: Hunter Biden; Hallie Biden; Beau Biden; Patrick Soon-Shiong; Al Yung MD
>> Subject: Re: next steps
>>
>> Mark,
>> Thank you once again for arranging this. I had a conversation with Al last night and he is on board with everything. He is in Hong Kong till Thursday but will be available to do a call with Patrick Tuesday at 4 PM PST if that works. He also realizes the time constraints we are under and doesn't want to miss any potential opportunities. I can arrange a call in number if that works for Patrick.
>> Warmly,
>> Howard
>>
>> Howard D. Krein MD, PhD
>> Assistant Professor
>> Div. of Facial Plastics and Reconstructive Surgery
>> Dept. of Otolaryngology/ Head and Surgery
>> Thomas Jefferson University
>> 215-955-6760
>>
>> StartUp Health
>> Chief Medical Officer
>> Howard@startuphealth.com
>>
>> On Mar 9, 2015, at 1:41 AM, Mark Hyman <Mark@ultrawellnesscenter.com> wrote:
>>
>>> Dear All,
>>>
>>> I am writing to connect everyone so Dr. Patrick can start the process of gaining access to records and set up integrated team meeting as the next step.
>>> Thanks for all your time today and allowing us to be part of your care team.
>>> I have also copied Dr. Yung so that he and Dr. Patrick can connect directly to expedite care coordination.
>>>
>>> Be well,
>>>
>>> Mark
>>> ------------------
>>> Mark Hyman, MD
>>> Director, Cleveland Clinic Center for Functional Medicine
>>> Founder and Medical Director
>>> The UltraWellness Center
>>> Chairman, Institute for Functional Medicine
>>> 55 Pittsfield Road, Suite 9
>>> Lenox Commons
>>> Lenox, MA 01240
>>> (413) 637-9991
>>> mark@drhyman.com
>>> www.drhyman.com
>>>
>>> Follow me:
>>> Facebook
>>> Twitter
>>> Linked In
>>>
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>
>
>
> --
> Howard D. Krein MD, PhD
> Assistant Professor
> Div. of Facial Plastics and Reconstructive Surgery
> Dept. of Otolaryngology/ Head and Surgery
> Thomas Jefferson University
> 215-955-6760
>
> Chief Medical Officer -StartUp Health
> startuphealth.co