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Al and Patrick,
As long as tomorrow at 4pm PST (7am Hong Kong) works I will send call in
number for the three of us to connect and further discuss options/plans as
well serve as an introduction.
thanks again and looking forward to speaking with both of you tomorrow
evening.
Warmly,
Howard

On Mon, Mar 9, 2015 at 8:16 PM, Yung,W K Alfred <wyung@mdanderson.org>
wrote:

> We have done deep molecular analysis on Beau's original tumor with our
> T200 panel and WGS. The profile is quite bland, not too many mutations is
> found, major GBM associated genes like EGFR, PTEN, PIK3CA, PDGFRA, HER2 are
> negative, only 2 positive hits: p53 and PTPN11. IHC showed increase pAKT,
> PDGFRA, pMAPK. Patrick's team have identified 10 over-expressed peptides
> for the preparation of an immuned-T-cell vaccine which we planned to use
> with the anti-PD1.
> I certainly welcome any help we can get. We have planned to do another
> round of deep molecule analysis of the new tumor after it is removed next
> week.
> Al
>
>
> W. K. Alfred Yung, M.D.
> Chair,Department of Neuro-Oncology
> UT M.D. Anderson Cancer Center
> 1515 Holcombe Blvd.
> Houston, TX 77030
> 713-794-1285
>
>
> From: Patrick Soon-Shiong <pss@nantworks.com>
> Date: Monday, March 9, 2015 9:36 AM
> To: Howard Krein <howard@startuphealth.com>, Mark Hyman <
> Mark@ultrawellnesscenter.com>
> Cc: Hunter Biden <rhb@rspdc.com>, Hallie Beiden <halliebiden@gmail.com>,
> Beau Biden <261penn@gmail.com>, Alfred Yung <wyung@mdanderson.org>, Kim
> Nicholson <Kim.Nicholson@swedish.org>, Phil Yang <phil.yang@nantworks.com>,
> Marci Rodriguez <Marci.Rodriguez@nantworks.com>, Shahrooz Rabizadeh <
> Shahrooz@nantworks.com>
> Subject: Re: next steps
>
>
> Dear Howard and Mark
> Happy to help in anyway we can. As a first step we should retieve the
> tissue (both the paraffin block and the fresh frozen) from the surgery
> performed a year ago. We could begin the panomic sequencing on that sample
> now and before the next surgery. We will look for eGfr and Her+ markers as
> potential targets for the NK92 treatment.
>
> Kim will reach out to you today. Also will coordinate a call for Tuesday
> with our team to review all images to date
>
> Keep well
> Patrick
> Sent from my BlackB
> erry 10 smartphone on the Verizon Wireless 4G LTE network.
> *From: *Howard Krein
> *Sent: *Monday, March 9, 2015 5:36 AM
> *To: *Mark Hyman
> *Cc: *Hunter Biden; Hallie Biden; Beau Biden; Patrick Soon-Shiong; Al
> Yung MD
> *Subject: *Re: next steps
>
> Mark,
> Thank you once again for arranging this. I had a conversation with Al last
> night and he is on board with everything. He is in Hong Kong till Thursday
> but will be available to do a call with Patrick Tuesday at *4 PM PST* if
> that works. He also realizes the time constraints we are under and doesn't
> want to miss any potential opportunities. I can arrange a call in number if
> that works for Patrick.
> Warmly,
> Howard
>
> Howard D. Krein MD, PhD
> Assistant Professor
> Div. of Facial Plastics and Reconstructive Surgery
> Dept. of Otolaryngology/ Head and Surgery
> Thomas Jefferson University
> 215-955-6760
>
> StartUp Health
> Chief Medical Officer
> Howard@startuphealth.com
>
> On Mar 9, 2015, at 1:41 AM, Mark Hyman <Mark@ultrawellnesscenter.com>
> wrote:
>
> Dear All,
>
> I am writing to connect everyone so Dr. Patrick can start the process of
> gaining access to records and set up integrated team meeting as the next
> step.
> Thanks for all your time today and allowing us to be part of your care
> team.
> I have also copied Dr. Yung so that he and Dr. Patrick can connect
> directly to expedite care coordination.
>
> Be well,
>
> Mark
> ------------------
> Mark Hyman, MD
> Director, Cleveland Clinic Center for Functional Medicine
> Founder and Medical Director
> The UltraWellness Center
> Chairman, Institute for Functional Medicine
> 55 Pittsfield Road, Suite 9
> Lenox Commons
> Lenox, MA 01240
> (413) 637-9991
> mark@drhyman.com
> www.drhyman.com
>
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>
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--
Howard D. Krein MD, PhD
Assistant Professor
Div. of Facial Plastics and Reconstructive Surgery
Dept. of Otolaryngology/ Head and Surgery
Thomas Jefferson University
215-955-6760

Chief Medical Officer -StartUp Health
startuphealth.co