EMAIL DETAILS

Hallie Olivere Biden
302-540-3774


Begin forwarded message:

> From: "Yung,W K Alfred" <wyung@mdanderson.org>
> Date: June 13, 2014, 1:54:47 PM CDT
> To: "Jon Glass MD (jon.glass@jefferson.edu)" <jon.glass@jefferson.edu>
> Cc: Beau Biden <261penn@gmail.com>, "Hallie (halliebiden@gmail.com)" <halliebiden@gmail.com>, "Krein Howard (howardkrein@yahoo.com)" <howardkrein@yahoo.com>
> Subject: patient
>
> Jon, I saw Beau this morning. He looks good. Speech is better than 2 months ago. Field cut is little better too.
> The MRI is also better than last one in May. I copy here a few images here for you (Hallie has the CD).
> I told him the rapid resolution of the contrast enhancement and the FLAIR suggest we are dealing with radiation damage in most of the area. We may still have some residual tumor in the left inferior border of the cavity. But I am happy to see the change is consistent with respond of radiation injury to Avastin.
> I told him I like to keep Avastin for another month (2 doses), at 7.5 mg/Kg, then stop. I want to use short term treatment so not to induce tumor invasive and malignant transformation. We can come back to use Avastin if we have to later.
> I also want to add BKM120 to lapatinib. I have gotten CIND permission from Novartis and we have the drug here. So I am starting him on BKM120 50 mg per day with Lapatinib at 750 mg per day. We will watch him carefully for side effect in skin.
> So here is the summary of his treatment plan we discussed today:
> 1) Avastin 7.5 mg/Kg for two doses more.
> 2) Macitentan 150 mg per day, daily
> 3) TMZ 125 mg/me, 6 days on 8 days off.
> 4) Lapatinib (tykerb) 750 mg per day, daily
> 5) BKM 120 50 mg per day daily.
> Thanks for taking care of Beau.
>
> Al
>
> W.K. Alfred Yung, M.D.
> Chairman, Department of Neuro-Oncology
> Margaret and Ben Love Chair in Clinical Cancer Care
> UT M. D. Anderson Cancer Center, Unit 431
> 1515 Holcombe Blvd
> Houston, TX 77030
> Tele: 713-794-1285
> Fax: 713-563-0151
> wyung@mdanderson.org
> =2